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KMID : 0882420120820030371
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Korean Journal of Medicine
2012 Volume.82 No. 3 p.371 ~ p.373
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Case of Linezolid-Associated Lactic Acidosis
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Lee Hong-Joo
Choi Jae-Ho
Kim Sun-Yong
Chung Kyung-Hwan
Lee Tae-Won
Ihm Chun-Gyoo
Moon Ju-Young
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Abstract
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Linezolid has been used for treatment of vancomycin-resistant Enterococcus faecium infection, nosocomial pneumonia caused by Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus or Streptococcus pneumoniae, and complicated and uncomplicated skin and skin structure infections. Lactic acidosis is an adverse effect associated with drugs, including metformin, the nucleoside reverse-transcriptase inhibitors and, rarely, linezolid. We report a case in which severe lactic acidosis developed as an adverse effect of linezolid in a 75-year-old woman who had been on linezolid for 30 days for treatment of a wound infection caused by methicillin-resistant coagulase-negative Staphylococcus. Discontinuation of linezolid and hemodialysis improved her lactic acidosis.
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KEYWORD
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Linezolid, Lactic acidosis
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